Quantitative proteomics analysis of lysine 2-hydroxyisobutyrylation in IgA nephropathy
نویسندگان
چکیده
Abstract Background Protein posttranslational modification is an indispensable regulatory element that can fine-tune protein functions and regulate diverse cellular processes. Lysine 2-hydroxyisobutyrylation (Khib) a was recently identified thought to play role in wide variety of active functions. Methods In this report, for the first time, we comparatively studied proteome peripheral blood mononuclear cells from biopsy-proven immunoglobulin A nephropathy (IgAN) group normal control based on liquid chromatography-tandem mass spectrometry. Results Altogether, 7405 proteins were added Khib library. Of these proteins, 111 with upregulated expression 83 downregulated expression. Furthermore, 428 sites 290 Khib-modified including 171 increased 122 257 specific reduced 168 proteins. Conclusions Importantly, abundance lipocalin 2 differentially expressed KEGG-based functional enrichment analysis showed clustered IL-17 signaling pathway phagosome category, which may have important associations IgAN. Our data enlighten our understanding IgAN indicate roles
منابع مشابه
IgA nephropathy.
A great interest in IgA nephropathy was demonstrated in the last few years. Unfortunately, a complete picture of this chronic disease should not yet been made. The article deals with 7 patients with IgA nephropathy treated in our Institute. The following characteristics were examined during a long period of time (1-17 years): clinical picture, course of the disease, clinical and morphologic cor...
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IgA nephropathy is glomerular disease first described in 1968 by Berger, named after him Morbus Berger. The disease is characterized by the presence of IgA dominant or codominant immunoglobulin deposits in glomerular mesangium which can be demonstrated by immunofluorescence. Clinical manifestations of IgA nephropathy in the majority of cases is hematuria which can be macro or microscopic, isola...
متن کاملIgA Nephropathy.
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ژورنال
عنوان ژورنال: Clinical Proteomics
سال: 2021
ISSN: ['1559-0275', '1542-6416']
DOI: https://doi.org/10.1186/s12014-021-09314-0